1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

Base Information

Chemical Name:1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene
CAS No.:213113-05-4
Molecular Formula:C₂₁H₂₄O₅
Molecular Weight:356.419
Hs Code.:

Synonyms:1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

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Chemical Property of 1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

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Technology Process of 1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

There total 3 articles about 1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 128557-02-8
4-bromo-7-methoxy-1,2-dihydronaphthalene

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 213113-05-4
1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tetlet.2005.06.016

Reference yield: 28.0%

: 70157-87-8
N'-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 213113-05-4
1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

Guidance literature:: N'-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-4-methylbenzenesulfonohydrazide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; at -50 - 20 ℃; for 1h; Cooling with acetone-dry ice;

3,4,5-trimethoxy-benzaldehyde; In hexane; at 0 ℃; for 1h;

Reference yield:

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 213113-05-4
1-(hydroxymethyl-3',4',5'-trimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / PBr₃ / benzene / 80 °C

2: 53 percent / n-BuLi / tetrahydrofuran / -78 °C

With n-butyllithium; phosphorus tribromide; In tetrahydrofuran; benzene;
DOI:10.1016/j.tetlet.2005.06.016