N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Base Information

• Chemical Name: N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide
• CAS No.: 1448317-83-6
• Molecular Formula: C₃₄H₃₂F₅N₇O₃S
• Molecular Weight: 713.731

Synonyms:N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

Chemical Property of N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

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Technology Process of N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

There total 9 articles about N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(morpholin-4-yl)-5-(pentafluoro-λ6-sulphanyl)benzoic acid (1448317-52-9) + 3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline trifluoroacetate → N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448317-83-6)

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

1-(2,2-diethoxyethyl)-1'-(4-methoxybenzyl)-N-(2-methyl-5-nitrophenyl)-1H,1'H-3,4'-bipyrazole-5-amine (1448317-27-8) → N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448317-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / ethanol / 0.58 h / 120 °C / Microwave irradiation

2: palladium 10% on activated carbon; ammonium formate / ethanol; water / 1 h / 90 °C / Microwave irradiation

3: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C

With 4-methyl-morpholine; sulfuric acid; palladium 10% on activated carbon; ammonium formate; HATU; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1-(2-methyl-5-nitrophenyl)-1H-imidazo-[1,2-b]pyrazole (1448317-28-9) → N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methyl-phenyl)-3-(morpholin-4-yl)-5-(pentafluoro-λ6-sulphanyl)benzamide (1448317-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 1 h / 90 °C / Microwave irradiation

2: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; ammonium formate; HATU; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(2,2-diethoxyethyl)-1'-(4-methoxybenzyl)-N-(2-methyl-5-nitrophenyl)-1H,1'H-3,4'-bipyrazole-5-amine

6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1-(2-methyl-5-nitrophenyl)-1H-imidazo-[1,2-b]pyrazole

3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzoic acid

3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

Downstream raw materials:

N-{4-methyl-3-[6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(morpholin-4-yl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

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