1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide

Base Information

• Chemical Name: 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide
• CAS No.: 95846-53-0
• Molecular Formula: C₂₉H₃₇N₃O₃S
• Molecular Weight: 507.697

Synonyms:1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide

Chemical Property of 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide

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Technology Process of 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide

There total 2 articles about 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-Methoxy-17β-hydroxyestra-1,3,5(10)-triene-17α-acetylhydrazide (95846-52-9) + 1-isothiocyanato-4-methylbenzene (622-59-3) → 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide (95846-53-0)

Guidance literature:

In ethanol; for 0.5h; Heating;

DOI:10.1002/jhet.5570210539

Reference yield:

<17β-Hydroxy-3-methoxy-oestra-1,3,5(10)-trien-17α-yl>-essigsaeure-aethylester (2445-35-4) → 1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide (95846-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NH₂NH₂*H₂O / 3.5 h / 115 °C

2: 99 percent / ethanol / 0.5 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570210539

Reference yield: 88.0%

1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-tolyl)-3'-thiosemicarbazide (95846-53-0) → 3-Methoxy-17α-<1'H-4'-(4-tolyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol (95846-59-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1002/jhet.5570210539

upstream raw materials:

3-Methoxy-17β-hydroxyestra-1,3,5(10)-triene-17α-acetylhydrazide

1-isothiocyanato-4-methylbenzene

<17β-Hydroxy-3-methoxy-oestra-1,3,5(10)-trien-17α-yl>-essigsaeure-aethylester

Downstream raw materials:

3-Methoxy-17α-<1'H-4'-(4-tolyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol

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