(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

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Chemical Name:(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate
CAS No.:1423567-39-8
Molecular Formula:C₃₃H₃₄FN₃O₃
Molecular Weight:539.65
Hs Code.:

Synonyms:(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

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Chemical Property of (R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

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Technology Process of (R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

There total 3 articles about (R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1423567-30-9
(+)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)-1-propanol

: 14649-03-7
(S)-phenylethyl isocyanate

: 1423567-39-8
(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

Guidance literature:: (+)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)-1-propanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

(S)-phenylethyl isocyanate; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/mp3006227

Reference yield:

: 1423566-63-5
(±)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)-1-propanol

: 1423567-39-8
(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.25 h / 20 °C / Molecular sieve

1.2: 2 h / 0 °C

2.1: (1S)-(+)-10-camphorsulfonic acid / methanol / 2 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

With n-butyllithium; (1S)-(+)-10-camphorsulfonic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/mp3006227

Reference yield:

: 1423567-62-7
C₂₇H₃₄FNO₂

: 1423567-39-8
(R)-1-(2-fluorophenyl)-2-methyl-2-(pyridin-3-yl)propyl N-[(S)-1-phenylethyl]-N-[(S)-1-phenylethyl-carbamoyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1S)-(+)-10-camphorsulfonic acid / methanol / 2 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

With n-butyllithium; (1S)-(+)-10-camphorsulfonic acid; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/mp3006227