N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Base Information

• Chemical Name: N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide
• CAS No.: 1160625-42-2
• Molecular Formula: C₂₂H₁₅ClF₂N₄OS
• Molecular Weight: 456.903

Synonyms:N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Chemical Property of N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Chemical Property:

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Technology Process of N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

There total 1 articles about N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiopropanamide (631-58-3) + C19H11BrClF2N3O2 (1160626-44-7) → N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide (1160625-42-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield: 57.0%

(3-fluoro-4-{[2-(1-pyrrolidinyl)ethyl]oxy}phenyl)amine hydrochloride + N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide (1160625-42-2) → N-(3-(2-ethyl-5-(2-((3-fluoro-4-((2-(1-pyrrolidinyl)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide (1160625-58-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 90 ℃;

Reference yield: 30.0%

N-(3-(5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide (1160625-42-2) + 4-(1,4'-bipiperidin-1'-yl)-3-fluorophenylamine hydrochloride → N-(3-(5-(2-((4-(1,4'-bipiperidin-1'-yl)-3-fluorophenyl)amino)-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide (1160625-52-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 90 ℃; for 72h;

upstream raw materials:

thiopropanamide

C₁₉H₁₁BrClF₂N₃O₂

Downstream raw materials:

N-(3-(5-(2-((4-((2-(dimethylamino)ethyl)oxy)-3-fluorophenyl)amino)-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

N-(3-(2-ethyl-5-(2-((3-fluoro-4-((2-(1-pyrrolidinyl)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

N-(3-(5-(2-((4-(1,4'-bipiperidin-1'-yl)-3-fluorophenyl)amino)-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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