2,3-difluorophenylazide

Base Information

• Chemical Name: 2,3-difluorophenylazide
• CAS No.: 123330-49-4
• Molecular Formula: C₆H₃F₂N₃
• Molecular Weight: 155.107
• Mol file: 123330-49-4.mol

Synonyms:2,3-difluorophenylazide

Chemical Property of 2,3-difluorophenylazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-difluorophenylazide

There total 1 articles about 2,3-difluorophenylazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-difluoroanilline (4519-40-8) → 2,3-difluorophenylazide (123330-49-4)

Guidance literature:

With sodium azide; sulfuric acid; trifluoroacetic acid; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, RT, 30 min, 2.) 1 h;

DOI:10.1021/jo00286a028

Reference yield: 90.0%

1-(naphthalen-2-yl)propan-2-one (21567-68-0) + 2,3-difluorophenylazide (123330-49-4) → 1-(2,3-difluorophenyl)-5-methyl-4-(naphthalen-2-yl)-1H-1,2,3-triazole

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 25 ℃; for 0.5h; regioselective reaction;

DOI:10.1002/chem.201405501

Reference yield: 66.0%

N-propargyl-2-methylene-3-oxo-olean-12-en-28-amide + 2,3-difluorophenylazide (123330-49-4) → N-((1-(2,3-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; butan-1-ol; at 35 ℃;

DOI:10.1016/j.bioorg.2020.104036

upstream raw materials:

2,3-difluoroanilline