tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

Base Information

Chemical Name:tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate
CAS No.:1417658-87-7
Molecular Formula:C₂₈H₂₉FN₂O₅
Molecular Weight:492.547
Hs Code.:

Synonyms:tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

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Chemical Property of tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

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Technology Process of tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

There total 6 articles about tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1417658-85-5
4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol

: 36293-63-7
tert-butyl 2-hydroxy-2-methylpropanoate

: 1417658-87-7
tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

Guidance literature:: With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

: 1417658-82-2
N-(2,6-dichloropyridin-3-yl)-4-methoxy-3,5-dimethylbenzamide

: 1417658-87-7
tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,10-Phenanthroline; copper(l) iodide; caesium carbonate / tetrahydrofuran / 2 h / 140 °C / Microwave irradiation

2: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 180 °C / Microwave irradiation

3: boron tribromide / dichloromethane / 4.5 h / 0 - 20 °C

4: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 20 h / 20 °C

With copper(l) iodide; 1,10-Phenanthroline; boron tribromide; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 62476-56-6
3-amino-2,6-dichloropyridine

: 1417658-87-7
tert-butyl 2-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2-methylpropionate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 17 h / 0 - 20 °C

2: 1,10-Phenanthroline; copper(l) iodide; caesium carbonate / tetrahydrofuran / 2 h / 140 °C / Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 180 °C / Microwave irradiation

4: boron tribromide / dichloromethane / 4.5 h / 0 - 20 °C

5: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 20 h / 20 °C

With pyridine; copper(l) iodide; 1,10-Phenanthroline; boron tribromide; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;