4-methyl-1,2,3,4-tetrahydrospiro

Base Information

• Chemical Name: 4-methyl-1,2,3,4-tetrahydrospiro
• CAS No.: 127934-39-8
• Molecular Formula: C₁₅H₂₁N
• Molecular Weight: 215.338
• Mol file: 127934-39-8.mol

Synonyms:4-methyl-1,2,3,4-tetrahydrospiro

Chemical Property of 4-methyl-1,2,3,4-tetrahydrospiro

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-1,2,3,4-tetrahydrospiro

There total 11 articles about 4-methyl-1,2,3,4-tetrahydrospiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-allyl-1-phenylaminocyclohexane (127934-37-6) → 4-methyl-1,2,3,4-tetrahydrospiro (127934-39-8)

Guidance literature:

With sulfuric acid; at 80 - 90 ℃;

DOI:10.1007/BF00481521

Reference yield: 62.5%

N-α-chloroacetyl-3,4-dihydro-4-methylspiro (153397-15-0) → 4-methyl-1,2,3,4-tetrahydrospiro (127934-39-8) + C15H21N (153397-27-4) + 3-methyl-4-chloroacetyloaminospiro

Guidance literature:

With boron trifluoride diethyl etherate; for 1h; Heating;

DOI:10.1007/BF00531546

Reference yield: 61.0%

N-(1-allylcyclohexyl)-N-(2'-benzylphenyl)amine (705269-17-6) → 4-methyl-1,2,3,4-tetrahydrospiro (127934-39-8) + 8'-benzyl-3',4'-dihydro-4'-methyl-1'H-spiro[cyclohexane-1,2'-quinoline]

Guidance literature:

With sulfuric acid; In chloroform; at 60 - 65 ℃; for 5h;

DOI:10.1002/ejoc.200400356

upstream raw materials:

1-allyl-1-phenylaminocyclohexane

N-acetyl-1,2,3,4-tetrahydro-4-methyl-1-acetylspiro

N-α-chloroacetyl-3,4-dihydro-4-methylspiro

1,2,3,4-tetrahydro-4-methyl-1-(α-bromopropionyl)spiro