N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

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Chemical Name:N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide
CAS No.:909124-91-0
Molecular Formula:C₃₁H₂₇BrClF₂NO₅S
Molecular Weight:678.979
Hs Code.:

<i>N</i>-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-<i>N</i>-(2,5-difluoro-phenyl)-benzenesulfonamide

Synonyms:N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

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Chemical Property of N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

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Technology Process of N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

There total 13 articles about N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 909124-89-6
N-(1-{2-(3-bromo-propoxy)-4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-benzoyl]-phenyl}-ethyl)-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

: 909124-91-0
N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 0 ℃;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 909124-64-7
3-hydroxy-4-iodo-N-methoxy-N-methyl-benzamide

: 909124-91-0
N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

2.1: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

3.1: 70 percent / formic acid / 60 °C

4.1: 97 percent / NaBH₄ / methanol / 0 °C

5.1: i-PrMgBr / tetrahydrofuran / -20 °C

5.2: 71 percent / tetrahydrofuran / -78 - 0 °C

6.1: 82 percent / PPh₃; DEAD / toluene / 0 - 20 °C

7.1: 95 percent / aq. HF / acetonitrile / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; formic acid; hydrogen fluoride; isopropylmagnesium bromide; triphenylphosphine; diethylazodicarboxylate; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile; 1.1: Sonogashira coupling / 2.1: Mitsunobu reaction / 6.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 909124-60-3
3-hydroxy-N-methoxy-N-methyl-4-nitro-benzamide

: 909124-91-0
N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 20 °C

2.1: NaNO₂; aq. HCl / 0 °C

2.2: 68 percent / KI / 20 °C

3.1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

4.1: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

5.1: 70 percent / formic acid / 60 °C

6.1: 97 percent / NaBH₄ / methanol / 0 °C

7.1: i-PrMgBr / tetrahydrofuran / -20 °C

7.2: 71 percent / tetrahydrofuran / -78 - 0 °C

8.1: 82 percent / PPh₃; DEAD / toluene / 0 - 20 °C

9.1: 95 percent / aq. HF / acetonitrile / 0 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; formic acid; hydrogen fluoride; hydrogen; isopropylmagnesium bromide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile; 3.1: Sonogashira coupling / 4.1: Mitsunobu reaction / 8.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091