(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

Base Information

Chemical Name:(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine
CAS No.:1352244-21-3
Molecular Formula:C₁₅H₁₅Cl₂N₃O₂S
Molecular Weight:372.275
Hs Code.:

Synonyms:(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

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Technology Process of (2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

There total 5 articles about (2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1352244-13-3
2-(propane-2-sulfonyl)-5-vinylphenylamine

: 5750-76-5
2,4,5-trichloropyrimidine

: 1352244-21-3
(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm201333e

Reference yield:

: 1352244-84-8
2-nitro-1-(propane-2-sulfonyl)-4-vinylbenzene

: 1352244-21-3
(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid / tetrahydrofuran / 16 h / 35 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With iron; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201333e

Reference yield:

: 1192471-71-8
4-bromo-1-isopropylsulfanyl-2-nitrobenzene

: 1352244-21-3
(2,5-dichloropyrimidin-4-yl)-[2-(propane-2-sulfonyl)-5-vinylphenyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

3: iron; acetic acid / tetrahydrofuran / 16 h / 35 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201333e