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Technology Process of Sant-1

Sant-1

Base Information
  • Chemical Name:Sant-1
  • CAS No.:304909-07-7
  • Molecular Formula:C23H27 N5
  • Molecular Weight:373.501
  • Hs Code.:
  • NSC Number:731871
  • DSSTox Substance ID:DTXSID90425965
  • Pharos Ligand ID:4J4NN1YLQSFU
  • ChEMBL ID:CHEMBL515916
  • Mol file:304909-07-7.mol
Sant-1

Synonyms:SANT-1;304909-07-7;CHEMBL515916;1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-;N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(E)-N-(4-BENZYLPIPERAZIN-1-YL)-1-(3,5-DIMETHYL-1-PHENYLPYRAZOL-4-YL)METHANIMINE;(E)-4-Benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene)piperazin-1-amine;MFCD01827306;(E)-N-(4-Benzylpiperazin-1-Yl)-1-(3,5-Dimethyl-1-Phenyl-1h-Pyrazol-4-Yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine;SCHEMBL1503099;SCHEMBL10063651;CHEBI:93466;DTXSID90425965;1-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-N-[4-(phenylmethyl)-1-piperazinyl]methanimine;FOORCIAZMIWALX-JJIBRWJFSA-N;HMS3412P14;HMS3676P14;EX-A1250;Tox21_500396;BDBM50249488;NSC731871;s7092;STL361943;AKOS001011845;CCG-265017;NSC-731871;NCGC00092291-01;NCGC00092291-03;NCGC00092291-08;NCGC00186003-01;NCGC00261081-01;AC-32719;AS-74256;UPCMLD0ENAT0503-7093:001;HY-100224;CS-0018354;J-017988;BRD-K83637872-001-01-7;4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene)piperazin-1-amine;4-benzyl-N-[(E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]piperazin-1-amine;N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine

Suppliers and Price of Sant-1
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Sigma-Aldrich
  • SANT-1 ≥98% (HPLC), powder
  • 5mg
  • $ 158.00
  • Sigma-Aldrich
  • SANT-1
  • 5mg
  • $ 151.70
  • Sigma-Aldrich
  • SANT-1 ≥98% (HPLC), powder
  • 25mg
  • $ 659.00
  • DC Chemicals
  • SANT-1 >98%
  • 1 g
  • $ 1400.00
  • DC Chemicals
  • SANT-1 >98%
  • 250 mg
  • $ 750.00
  • ChemScene
  • SANT-1 99.85%
  • 100mg
  • $ 450.00
  • ChemScene
  • SANT-1 99.85%
  • 50mg
  • $ 250.00
  • ChemScene
  • SANT-1 99.85%
  • 10mg
  • $ 90.00
  • ChemScene
  • SANT-1 99.85%
  • 5mg
  • $ 55.00
  • Cayman Chemical
  • SANT 1 ≥98%
  • 10mg
  • $ 137.00
Total 19 raw suppliers
Chemical Property of Sant-1
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:104-106°C 
  • Boiling Point:547.4°Cat760mmHg 
  • PKA:7.35±0.10(Predicted) 
  • Flash Point:284.8°C 
  • PSA：36.66000 
  • Density:1.13g/cm3 
  • LogP:3.51660 
  • Storage Temp.:−20°C 
  • Sensitive.:Moisture & Light Sensitive 
  • Solubility.:Soluble in DMSO with warming 
  • XLogP3:4.2
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:5
  • Exact Mass:373.22664588
  • Heavy Atom Count:28
  • Complexity:489
Purity/Quality:

99%, *data from raw suppliers

SANT-1 ≥98% (HPLC), powder *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4
  • Isomeric SMILES:CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4
  • Description Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.
  • Uses A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G pro tein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.
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