[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

Base Information

Chemical Name:[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate
CAS No.:1347749-34-1
Molecular Formula:C₂₂H₂₅F₉N₅O₅P
Molecular Weight:641.43
Hs Code.:

[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

Synonyms:[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

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Chemical Property of [1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

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Technology Process of [1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

There total 3 articles about [1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1347749-24-9
methyl-phosphonic acid prop-2-ynyl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: 1347749-27-2
N-(2-azidoethyl)-2-methyl-2-[(phenylmethyl)(trifluoroacetyl)amino]-propanamide

: 1347749-34-1
[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; at 40 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.09.030

Reference yield:

: C₇H₇F₆O₃P

: 1347749-34-1
[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / Reflux

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 1 h / 40 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; dichloromethane; water; 2: Huisgen 1,3-dipolar cycloaddition reaction;
DOI:10.1016/j.bmcl.2011.09.030

Reference yield:

: 100-46-9
benzylamine

: 1347749-34-1
[1-(2-{[N-benzyl-2-methyl-N-(trifluoroacetyl)alanyl]amino}ethyl)-1H-1,2,3-triazol-4-yl]methyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 1 h / 40 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In methanol; dichloromethane; water; 1: Ugi reaction / 2: Huisgen 1,3-dipolar cycloaddition reaction;
DOI:10.1016/j.bmcl.2011.09.030