(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

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Chemical Name:(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea
CAS No.:1076690-60-2
Molecular Formula:C₂₀H₂₁ClN₄O₄
Molecular Weight:416.864
Hs Code.:

Synonyms:(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

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Chemical Property of (4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

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Technology Process of (4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

There total 5 articles about (4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1076690-92-0
(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-carbamic acid 4-nitro-phenyl ester

: 1076690-60-2
(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

Guidance literature:: With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; at 20 ℃; for 0.75h;

Reference yield:

: 2898-63-7
2-(2-chloro-4,5-dimethoxyphenyl)acetic acid

: 1076690-60-2
(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.62 h / 0 - 20 °C

1.2: 1.5 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 17.5 h / 20 °C

3.1: acetonitrile / 25.02 h / 20 °C

4.1: ammonia / 1-methyl-pyrrolidin-2-one; methanol / 0.75 h / 20 °C

With oxalyl dichloride; ammonia; hydrogen; palladium 10% on activated carbon; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1076690-60-2
(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxone(R); potassium chloride / water; acetonitrile / 1 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.62 h / 0 - 20 °C

2.2: 1.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / acetonitrile / 17.5 h / 20 °C

4.1: acetonitrile / 25.02 h / 20 °C

5.1: ammonia / 1-methyl-pyrrolidin-2-one; methanol / 0.75 h / 20 °C

With oxone(R); oxalyl dichloride; potassium chloride; ammonia; hydrogen; palladium 10% on activated carbon; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; acetonitrile;