{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:618902-62-8
Molecular Formula:C₄₆H₆₉N₇O₁₃S₂Si
Molecular Weight:1020.31
Hs Code.:

{4-[{3-[{3-[3-(4-<i>tert</i>-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Synonyms:{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of {4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of {4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 10 articles about {4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 618902-50-4
N-(1-oxobutyl)-O-(tert-butyl)tyrosine pentafluorophenyl ester

: 618902-61-7
{4-[{3-[(3-amino-propyl)-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

: 618902-62-8
{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;
DOI:10.1002/ejoc.200300186

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 618902-62-8
{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / Et₃N / CH₂Cl₂ / 4 h

2: 89 percent / DIPEA / tetrahydrofuran / 2 h / 50 °C

3: 70 percent / tributylphosphane; 1,1'-(azodicarbonyl)dipiperidide / tetrahydrofuran / 24 h / 20 °C

4: 68 percent / trimethylphosphane; 1,1'-(azodicarbonyl)dipiperidide / tetrahydrofuran / 40 h / 20 °C

5: 70 percent / p-toluenesulfonic acid / diethyl ether / 1 h / 50 °C

6: 76 percent / DIPEA / dimethylformamide / 2 h

With 1,1'-carbonyldipiperidine; tributylphosphine; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Fukuyama-Mitsunobu coupling / 4: Fukuyama-Mitsunobu coupling;
DOI:10.1002/ejoc.200300186

Reference yield:

: 18822-59-8,4727-00-8,186698-58-8
(+/-)-O-(tert-butyl)tyrosine

: 618902-62-8
{4-[{3-[{3-[3-(4-tert-butoxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / tetrahydrofuran / 3 h / 20 °C

2: 672 mg / pyridine / dimethylformamide / 5 h

3: 76 percent / DIPEA / dimethylformamide / 2 h

With pyridine; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300186