H-Asp(OBn)-Phe-NH₂ trifluoroacetate

Base Information

• Chemical Name: H-Asp(OBn)-Phe-NH₂ trifluoroacetate
• CAS No.: 60058-91-5
• Molecular Formula: C₂HF₃O₂*C₂₀H₂₃N₃O₄
• Molecular Weight: 483.444
• Mol file: 60058-91-5.mol

Synonyms:H-Asp(OBn)-Phe-NH₂ trifluoroacetate

Chemical Property of H-Asp(OBn)-Phe-NH₂ trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Asp(OBn)-Phe-NH₂ trifluoroacetate

There total 6 articles about H-Asp(OBn)-Phe-NH₂ trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(tert-butyloxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine amide (60058-69-7) + trifluoroacetic acid (76-05-1) → H-Asp(OBn)-Phe-NH2 trifluoroacetate (60058-91-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/jm00389a002

Reference yield:

(tert-butyloxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine amide (60058-69-7) → H-Asp(OBn)-Phe-NH2 trifluoroacetate (60058-91-5)

Guidance literature:

With TFA-anisole; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.30.2604

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → H-Asp(OBn)-Phe-NH2 trifluoroacetate (60058-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / <(benzotriazolyl)oxy>tris(dimethylaminophosphonium hexafluorophosphate (BOP), N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

2: trifluoroacetic acid / diethyl ether / 0.5 h / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a020

upstream raw materials:

(tert-butyloxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine amide

trifluoroacetic acid

(S)-2-tert-Butoxycarbonylamino-succinic acid 4-benzyl ester 1-(4-nitro-phenyl) ester

BOC-L-aspartic acid 4-benzyl ester

Downstream raw materials:

Boc-Met(O)-Asp(OBzl)-Phe-NH₂

Z-Orn(Boc)-Asp(OBzl)-Phe-NH₂

C₅₇H₆₈N₁₀O₁₃

(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-ψ(CH2-NH)-β-benzyl-L-aspartyl-L-phenylalanine amide