(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

Base Information

Chemical Name:(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol
CAS No.:207674-03-1
Molecular Formula:C₂₅H₂₆N₄O₅
Molecular Weight:462.505
Hs Code.:

Synonyms:(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

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Chemical Property of (2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

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Technology Process of (2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

There total 1 articles about (2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 207674-02-0
2,6-Dichloro-9-(4',6'-di-O-benzoyl-2',3'-dideoxy-β-D-glucopyranosyl)purin

: 100-51-6,185532-71-2
benzyl alcohol

: 207674-03-1
(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

Guidance literature:: With sodium; at 80 ℃; for 4h;
DOI:10.1002/hlca.19980810302

Reference yield: 83.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 207674-03-1
(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

: 207674-24-6
(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

Guidance literature:: With tetrabutylammonium perchlorate; In pyridine; for 1.5h; Ambient temperature;
DOI:10.1002/hlca.19980810302

Reference yield:

: 207674-03-1
(2R,3S,6R)-6-(2,6-Bis-benzyloxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-pyran-3-ol

: Diisopropyl-phosphoramidous acid (2R,3S,6R)-6-(2,6-bis-benzyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / (Bu₄N)ClO₄ / pyridine / 1.5 h / Ambient temperature

2: 94 percent / (i-Pr)2EtN / tetrahydrofuran / 1 h / Ambient temperature

With tetrabutylammonium perchlorate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.19980810302