1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Base Information

Chemical Name:1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine
CAS No.:217318-34-8
Molecular Formula:C₁₈H₁₅NO₂
Molecular Weight:277.323
Hs Code.:

Synonyms:1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Suppliers and Price of 1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

There total 11 articles about 1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 217318-33-7
1-ethyl-6-methoxy-2-(4-methoxyphenyl)pyrrolo[2,1,5-cd]indolizine

: 217318-34-8
1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Guidance literature:: With boron tribromide; In dichloromethane; at -70 - 20 ℃;

Reference yield:

: 622-39-9
2-propylpyridine

: 217318-34-8
1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Guidance literature:: Multi-step reaction with 9 steps

1.1: H₂O₂ / acetic acid / 13 h / 75 °C

2.1: HNO₃; H₂SO₄ / 22 h / 70 °C

3.1: methanol / 25 °C

4.1: Zn; H₂SO₄ / 12 h / 75 °C

5.1: acetone / Heating

5.2: aq. NaHCO₃ / Heating

6.1: toluene / 0 °C

6.2: DDQ / Heating

7.1: aq. KOH / methanol / Heating

8.1: Cu; quinoline / 170 °C

9.1: BBr₃ / CH₂Cl₂ / -65 - 25 °C

With quinoline; potassium hydroxide; sulfuric acid; dihydrogen peroxide; nitric acid; boron tribromide; copper; zinc; In methanol; dichloromethane; acetic acid; acetone; toluene; 1.1: Oxidation / 2.1: Nitration / 3.1: Substitution / 4.1: Reduction / 5.1: quaternization / 5.2: Cyclization / 6.1: Cycloaddition / 6.2: Oxidation / 7.1: Hydrolysis / 8.1: Decarboxylation / 9.1: demethylation;
DOI:10.1016/S0960-894X(00)00474-1

Reference yield:

: 20609-07-8
2-propyl-pyridine N-oxide

: 217318-34-8
1-ethyl-6-hydroxy-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine

Guidance literature:: Multi-step reaction with 8 steps

1.1: HNO₃; H₂SO₄ / 22 h / 70 °C

2.1: methanol / 25 °C

3.1: Zn; H₂SO₄ / 12 h / 75 °C

4.1: acetone / Heating

4.2: aq. NaHCO₃ / Heating

5.1: toluene / 0 °C

5.2: DDQ / Heating

6.1: aq. KOH / methanol / Heating

7.1: Cu; quinoline / 170 °C

8.1: BBr₃ / CH₂Cl₂ / -65 - 25 °C

With quinoline; potassium hydroxide; sulfuric acid; nitric acid; boron tribromide; copper; zinc; In methanol; dichloromethane; acetone; toluene; 1.1: Nitration / 2.1: Substitution / 3.1: Reduction / 4.1: quaternization / 4.2: Cyclization / 5.1: Cycloaddition / 5.2: Oxidation / 6.1: Hydrolysis / 7.1: Decarboxylation / 8.1: demethylation;
DOI:10.1016/S0960-894X(00)00474-1