H-D-LEU-OTBU HCL

Base Information

• Chemical Name: H-D-LEU-OTBU HCL
• CAS No.: 13081-32-8
• Molecular Formula: C₁₀H₂₁NO₂*ClH
• Molecular Weight: 223.743
• Mol file: 13081-32-8.mol

Synonyms:D-Leucine,1,1-dimethylethyl ester, hydrochloride (9CI); Leucine, tert-butyl ester,hydrochloride, D- (8CI); (R)-2-Amino-4-methylpentanoic acid tert-butyl esterhydrochloride salt; D-Leucine tert-butyl ester hydrochloride

Chemical Property of H-D-LEU-OTBU HCL

Chemical Property:

• Refractive Index: -19 ° (C=2, EtOH)
• PSA: 52.32000
• LogP: 3.20380
• Storage Temp.: -15°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Leucine tert-Butyl Ester Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Leucine tert-butyl ester hydrochloride is a protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.

Technology Process of H-D-LEU-OTBU HCL

There total 1 articles about H-D-LEU-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ D-leucine tert-butyl ester hydrochloride (13081-32-8)

Guidance literature:

Reference yield: 100.0%

3-nitro-4-fluorobenzoic acid (453-71-4) + L-leucine tert-butyl ester hydrochloride (2748-02-9,13081-32-8) → (S)-2-(4-fluoro-3-nitro-benzoylamino)-4-methyl-pentanoic acid tert-butyl ester (1586791-32-3)

Guidance literature:

3-nitro-4-fluorobenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

L-leucine tert-butyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 4h;

Reference yield: 100.0%

4-(1-ethyl-propylamino)-3-nitro-benzoic acid (691363-43-6) + L-leucine tert-butyl ester hydrochloride (2748-02-9,13081-32-8) → (S)-2-[4-(1-ethyl-propylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester (1586791-35-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Downstream raw materials:

Z-Leu-Leu-OtBu

(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)-4-methylpentanoate

NPSLeu-Ser(Bzl)-LeuO-t-Bu

(S)-2-[(S)-2-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester

Refernces

• 1、 -. "N-cyclopentyl modulators of chemokine receptor activity". . . Retrieved 2008/06/13.