5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester
CAS No.:219487-92-0
Molecular Formula:C₁₉H₁₆N₄O₃
Molecular Weight:348.361
Hs Code.:

Synonyms:5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

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Chemical Property of 5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

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Technology Process of 5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

There total 4 articles about 5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 219487-83-9
C₁₉H₁₇ClN₄O₃

: 219487-92-0
5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

Guidance literature:: With silver carbonate; In 1,4-dioxane; for 120h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00922-3

Reference yield:

: 3010-05-7
benzylaminoacetonitrile

: 219487-92-0
5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / toluene / 5 h / Heating

2: 35 percent / Fe, aq. AcOH / ethanol / 2.5 h / Heating

3: 1.) aq. HCl, NaNO₂, 2.) NaOAc / 1.) MeOH, 0-5 deg C, 30 min, 2.) 0-5 deg C, 4 h, then room temp., 15 h

4: 95 percent / Ag₂CO₃ / dioxane / 120 h / Ambient temperature

With hydrogenchloride; sodium acetate; iron; potassium carbonate; acetic acid; silver carbonate; sodium nitrite; In 1,4-dioxane; ethanol; toluene;
DOI:10.1016/S0040-4020(98)00922-3

Reference yield:

: 35118-29-7
N-benzyl-N-cyanomethyl-2-nitrobenzamide

: 219487-92-0
5-Benzyl-6-oxo-5,6-dihydro-4H-1,3,5,10b-tetraaza-benzo[e]azulene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / Fe, aq. AcOH / ethanol / 2.5 h / Heating

2: 1.) aq. HCl, NaNO₂, 2.) NaOAc / 1.) MeOH, 0-5 deg C, 30 min, 2.) 0-5 deg C, 4 h, then room temp., 15 h

3: 95 percent / Ag₂CO₃ / dioxane / 120 h / Ambient temperature

With hydrogenchloride; sodium acetate; iron; acetic acid; silver carbonate; sodium nitrite; In 1,4-dioxane; ethanol;
DOI:10.1016/S0040-4020(98)00922-3