2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

Base Information

Chemical Name:2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol
CAS No.:871210-09-2
Molecular Formula:C₂₉H₂₅F₂₆NO₃
Molecular Weight:929.481
Hs Code.:

Synonyms:2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

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Chemical Property of 2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

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Technology Process of 2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

There total 4 articles about 2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124947-31-5
N-(isopropoxycarbonyl)-L-phenylalanine methyl ester

: 871210-04-7
2(S)-(iso-propoxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

: 871210-09-2
2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

Guidance literature:: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane; With magnesium; In diethyl ether; for 90h;

N-(isopropoxycarbonyl)-L-phenylalanine methyl ester; In diethyl ether; for 4h; Product distribution / selectivity;

Reference yield:

: 2043-57-4,71215-70-8
1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

: 124947-31-5
N-(isopropoxycarbonyl)-L-phenylalanine methyl ester

: 871210-04-7
2(S)-(iso-propoxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

: 871210-09-2
2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

Guidance literature:: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane; With tert.-butyl lithium; In diethyl ether; hexane; at -78 - -60 ℃;

N-(isopropoxycarbonyl)-L-phenylalanine methyl ester; In diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1021/jo051696n

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 871210-09-2
2(S)-(iso-propoxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / SOCl₂ / 4 h / Heating

2.1: 70 percent / triethylamine / tetrahydrofuran; hexane / 2 h / 0 °C

3.1: t-BuLi / diethyl ether; hexane / -78 - -60 °C

3.2: diethyl ether; hexane / -78 - 20 °C

With thionyl chloride; tert.-butyl lithium; triethylamine; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo051696n