2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

Base Information

Chemical Name:2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile
CAS No.:1443221-78-0
Molecular Formula:C₃₂H₂₀ClF₂N₅O₂
Molecular Weight:579.993
Hs Code.:

Synonyms:2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

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Chemical Property of 2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

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Technology Process of 2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

There total 5 articles about 2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1443221-64-4
C₁₇H₉ClN₂O₂

: 1443221-90-6
C₁₂H₁₁F₂NO

: 109-77-3
malononitrile

: 1443221-78-0
2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

Guidance literature:: With piperidine; In ethanol; Reflux;
DOI:10.1016/j.ejmech.2013.03.017

Reference yield:

: 73568-41-9
2,6-dichloroquinoline-3-carbaldehyde

: 1443221-78-0
2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: piperidine / ethanol / Reflux

With piperidine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.03.017

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 1443221-78-0
2'-amino-6-chloro-2-(4-cyanophenoxy)-1'-(2,5-difluorophenyl)-5'-oxo-1',4',5',6',7',8'-hexahydro-3,4'-biquinoline-3'-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / methanol / Reflux

2: piperidine / ethanol / Reflux

With piperidine; acetic acid; In methanol; ethanol;
DOI:10.1016/j.ejmech.2013.03.017