Chemical Property of 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Chemical Property:
- Vapor Pressure:2.9E-09mmHg at 25°C
- Refractive Index:1.655
- Boiling Point:477 °C at 760 mmHg
- PKA:15.20±0.30(Predicted)
- Flash Point:242.3 °C
- PSA：39.34000
- Density:1.322 g/cm3
- LogP:2.08470
- Storage Temp.:Store at +4°C
- Solubility.:H2O: insoluble
- XLogP3:2.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:277.0981898
- Heavy Atom Count:19
- Complexity:344
- Purity/Quality:
-
99%, *data from raw suppliers
JNJ7777120 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl
-
Uses
JNJ7777120 is a histamine 4 receptor (H4R) antagonist on CCL17 and CCL22 chemokine production by human monocyte-derived Langerhans cells in patients with atopic dermatitis. JNJ7777120 has been used as a histamine-4 receptor antagonist:to study its effects on the pro-inflammatory microglia in ratsto study its effects on the Parkinson′s-like pathology in rat brainto study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
