2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

Base Information

Chemical Name:2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid
CAS No.:1258945-91-3
Molecular Formula:C₂₈H₄₀N₆O₁₀S
Molecular Weight:652.726
Hs Code.:

Synonyms:2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

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Chemical Property of 2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

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Technology Process of 2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

There total 11 articles about 2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 463-71-8
thiophosgene

: 1258945-90-2
2-{[1-(4-aminophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl](carboxymethyl)amino}acetic acid

: 1258945-91-3
2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

Guidance literature:: In chloroform; water; at 20 ℃; for 4h;

Reference yield:

: CSCl₂

: 161053-46-9
(S)-(-)-2-methoxy-2'-diphenylphosphino-1,1'-binaphthyl

: 1258945-91-3
2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

Guidance literature:: In chloroform; water;

Reference yield:

: 1005484-23-0
tert-butyl 2-(4-nitrobenzyl)aziridine 1-carboxylate

: 1258945-91-3
2-[(carboxymethyl)[1-(4-isothiocyanatophenyl)-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propan-2-yl]amino]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetonitrile

2: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C / Cooling with ice

3: sodium hydroxide / chloroform; water / pH 7

4: potassium carbonate / acetonitrile / 8 h / 65 °C

5: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C / Cooling with ice

6: palladium 10% on activated carbon; hydrogen / water / 14 h / 20 °C / 775.74 - 1034.32 Torr / Inert atmosphere

7: water / 4 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium hydroxide; In 1,4-dioxane; chloroform; water; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.107