4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid

Base Information

• Chemical Name: 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid
• CAS No.: 884851-09-6
• Molecular Formula: C₂₆H₂₄N₂O₄
• Molecular Weight: 428.488

Synonyms:4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid

Chemical Property of 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid

Chemical Property:

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Technology Process of 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid

There total 3 articles about 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid ethyl ester → 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid (884851-09-6)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; for 10h; Heating;

DOI:10.1002/ejoc.200500642

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid (884851-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃; 18-crown-6 / acetone / 60 h / Heating

2: 93.4 percent / KOH / tetrahydrofuran; methanol / 10 h / Heating

With potassium hydroxide; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1002/ejoc.200500642

Reference yield:

2-[4-(bromomethyl)phenyl]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (253878-40-9) → 4-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzyloxy}-benzoic acid (884851-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃; 18-crown-6 / acetone / 60 h / Heating

2: 93.4 percent / KOH / tetrahydrofuran; methanol / 10 h / Heating

With potassium hydroxide; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1002/ejoc.200500642

upstream raw materials:

Ethyl 4-hydroxybenzoate

2-[4-(bromomethyl)phenyl]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

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