(4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

Base Information

Chemical Name:(4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one
CAS No.:928053-53-6
Molecular Formula:C₁₇H₁₈F₂N₂O
Molecular Weight:304.34
Hs Code.:

Synonyms:(4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

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Chemical Property of (4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

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Technology Process of (4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

There total 2 articles about (4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 928053-52-5
N'-(2,4-difluoro-phenyl)-N'-((1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl)-hydrazinecarboxylic acid tert-butyl ester

: 928053-53-6
(4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4.25h; Product distribution / selectivity;

Reference yield: 47.0%

: 928053-36-5,129940-80-3
(1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl chloride

: 928053-37-6
N-(2,4-difluoro-phenyl)-N'-ethylidene-hydrazine

: 928053-53-6
(4R,7S)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one

Guidance literature:: (1S,4S)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]heptane-2-carbonyl chloride; N-(2,4-difluoro-phenyl)-N'-ethylidene-hydrazine; With pyridine; In 1,2-dichloro-ethane; at 20 - 50 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h;

With acetic acid; In 1,4-dioxane; 1,2-dichloro-ethane; at 100 ℃; for 1h; Product distribution / selectivity;