(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

Base Information

Chemical Name:(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol
CAS No.:1429118-79-5
Molecular Formula:C₃₃H₃₅NO₅
Molecular Weight:525.645
Hs Code.:

Synonyms:(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

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Chemical Property of (S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

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Technology Process of (S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

There total 15 articles about (S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422431-48-8
(S)-2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxybenzyl acetate

: 1429118-79-5
(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 1429118-79-5
(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 14 h / Reflux

2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

3: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere

4: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C

5: water; sodium hydroxide / ethanol / 3 h / 20 °C

With pyridine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; water; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1429118-79-5
(S)-(2-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid; bromine / 2 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: phenylboronic acid / toluene / 1 h / Reflux; Dean-Stark

4.2: 46 h / 100 °C / Molecular sieve; Sealed tube

4.3: 2 h / Reflux

5.1: potassium carbonate / acetone / 4 h / Reflux

6.1: ethanol / 14 h / Reflux

7.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

8.1: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere

9.1: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C

10.1: water; sodium hydroxide / ethanol / 3 h / 20 °C

With pyridine; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); formic acid; water; bromine; copper; potassium carbonate; acetic acid; triethylamine; copper(II) oxide; potassium hydroxide; sodium hydroxide; trichlorophosphate; phenylboronic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 8.1: |Bischler-Napieralski Reaction;
DOI:10.1016/j.bmc.2012.12.016