S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

Base Information

Chemical Name:S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole
CAS No.:1027477-06-0
Molecular Formula:C₂₁H₂₅NO₆S
Molecular Weight:419.499
Hs Code.:

Synonyms:S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

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Technology Process of S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

There total 4 articles about S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

: 156781-21-4
ethyl 4-<2-(bis-acetoxymethylphenylsulfonylamino)ethyl>phenoxyacetate

: 1027477-06-0
S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

Guidance literature:: With sodium ethanolate; In ethanol; for 10h; Ambient temperature;
DOI:10.1248/cpb.42.521

Reference yield:

: 1008-72-6
sodium 2-formylbenzenesulfonate

: 1027477-06-0
S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 35.9 percent / SOCl₂, DMF / 0.05 h / 100 °C

2: 83 percent / conc. H₂SO₄ / 0.5 h

3: 94.6 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 74.7 percent / EtONa / ethanol / 10 h / Ambient temperature

With thionyl chloride; sulfuric acid; sodium ethanolate; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.521

Reference yield:

: 156781-20-3
2-(bis-acetoxymethyl)phenylsulfonyl chloride

: 1027477-06-0
S,S-dioxo-2,3-dihydro-3-ethoxy-2-<2-(4-ethoxycarbonylmethoxy)phenyl>benzoisothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 94.6 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 74.7 percent / EtONa / ethanol / 10 h / Ambient temperature

With sodium ethanolate; triethylamine; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.521