Chemical Property of 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
Chemical Property:
- Vapor Pressure:6.75E-14mmHg at 25°C
- Melting Point:111℃
- Refractive Index:1.706
- Boiling Point:590 °C at 760 mmHg
- PKA:8.77±0.70(Predicted)
- Flash Point:310.6 °C
- PSA：87.72000
- Density:1.27g/cm3
- LogP:5.78680
- Storage Temp.:Store at -20°C
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:421.13611680
- Heavy Atom Count:31
- Complexity:609
- Purity/Quality:
-
99%, *data from raw suppliers
A 83-01 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
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Description
A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2?IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2?Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency.3?Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts.4?Cell permeable. Active in vivo.
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Uses
A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability. A 83-01 has been used as an inhibitor of transforming growth factor β kinase type 1 receptor.
