2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1564256-31-0
Molecular Formula:C₂₆H₃₁ClN₆O₂
Molecular Weight:495.024
Hs Code.:

Synonyms:2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

There total 3 articles about 2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.7%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1564256-85-4
C₁₄H₂₂N₂O

: 1564256-31-0
2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 10-methoxy-3-methyl-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine

: 1564256-31-0
2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium nitrate; trifluoroacetic anhydride / acetonitrile / 2 h / Heating

2: iron; ammonium chloride

3: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With (1S)-10-camphorsulfonic acid; iron; ammonium chloride; potassium nitrate; trifluoroacetic anhydride; In isopropyl alcohol; acetonitrile;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-81-0
C₁₄H₂₀N₂O₃

: 1564256-31-0
2-((5-chloro-2-((11-methoxy-3-methyl-1,2,3,4,5,6,7,8-octahydrobenzo[d]azecin-10-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride

2: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With (1S)-10-camphorsulfonic acid; iron; ammonium chloride; In isopropyl alcohol;
DOI:10.1021/ml400373j