Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester

Base Information

• Chemical Name: Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester
• CAS No.: 160281-65-2
• Molecular Formula: C₁₅H₁₇BrO₅S
• Molecular Weight: 389.267
• Mol file: 160281-65-2.mol

Synonyms:Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester

Chemical Property of Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester

There total 4 articles about Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Methanesulfonic acid 5-bromo-2-methyl-4-(6-methyl-7-oxo-1,4-dioxa-spiro[4.4]non-6-ylmethyl)-phenyl ester (170168-28-2) → Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester (160281-65-2)

Guidance literature:

With sulfuric acid; In methanol; for 1h; Ambient temperature;

DOI:10.1016/0040-4020(95)00517-C

Reference yield: 38.0%

2-Methylcyclopentane-1,3-dione (765-69-5) + 2-bromo-4-mesyloxy-5-methylbenzyl bromide (160281-71-0) → Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester (160281-65-2) + Methanesulfonic acid 5-bromo-2-methyl-4-(2-methyl-3-oxo-cyclopent-1-enyloxymethyl)-phenyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.1h;

DOI:10.1016/0040-4020(95)00517-C

Reference yield: 37.0%

2-Methylcyclopentane-1,3-dione (765-69-5) + 2-bromo-4-mesyloxy-5-methylbenzyl iodide → Methanesulfonic acid 5-bromo-2-methyl-4-(1-methyl-2,5-dioxo-cyclopentylmethyl)-phenyl ester (160281-65-2) + Methanesulfonic acid 5-bromo-2-methyl-4-(2-methyl-3-oxo-cyclopent-1-enyloxymethyl)-phenyl ester

Guidance literature:

With potassium carbonate; In water; tert-butyl alcohol; for 3h; Heating;

DOI:10.1016/0040-4020(95)00517-C

upstream raw materials:

2-Methylcyclopentane-1,3-dione

2-bromo-4-mesyloxy-5-methylbenzyl bromide

Methanesulfonic acid 5-bromo-2-methyl-4-(6-methyl-7-oxo-1,4-dioxa-spiro[4.4]non-6-ylmethyl)-phenyl ester

Downstream raw materials:

6-(2-Bromo-4-methoxy-5-methyl-benzyl)-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

6-(2-Bromo-4-hydroxy-5-methyl-benzyl)-6-methyl-1,4-dioxa-spiro[4.4]nonan-7-one

(+/-)-parvifoline

Methanesulfonic acid 5-bromo-2-methyl-4-(6-methyl-7-oxo-1,4-dioxa-spiro[4.4]non-6-ylmethyl)-phenyl ester