3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide

Base Information

• Chemical Name: 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide
• CAS No.: 1616679-28-7
• Molecular Formula: C₁₅H₁₃F₃N₂O₅S₂
• Molecular Weight: 422.406
• Mol file: 1616679-28-7.mol

Synonyms:3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide

Chemical Property of 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide

There total 7 articles about 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

2-amino-4-[(trifluoromethyl)sulfinyl]phenol (1616682-59-7) + 3-(ethylsulfonyl)pyridine-2-carboxylic acid chloride (1421953-21-0) → 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide (1616679-28-7)

Guidance literature:

In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; at 0 ℃; for 5h; Solvent; Inert atmosphere;

Reference yield: 77.0%

2-amino-4-[(trifluoromethyl)sulfinyl]phenol (1616682-59-7) + 3-(ethylsulfonyl)-2-pyridinecarboxylic acid (1421953-17-4) → 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide (1616679-28-7)

Guidance literature:

3-(ethylsulfonyl)-2-pyridinecarboxylic acid; With thionyl chloride; In toluene; at 10 - 20 ℃; for 0.1h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In toluene; at 10 ℃; for 19h; Inert atmosphere;

2-amino-4-[(trifluoromethyl)sulfinyl]phenol; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 5 - 25 ℃; for 24h; Inert atmosphere;

Reference yield:

2-nitro-4-(trifluoromethylsulfinyl)phenol (1616682-58-6) → 3-ethylsulfonyl-N-[2-hydroxy-5-(trifluoromethylsulfinyl)phenyl]picolinamide (1616679-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / ethanol / 6 h / 35 °C

2: tetrahydrofuran / 18 h / 20 °C / Cooling with ice

With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; ethanol;

upstream raw materials:

(4-trifluoromethylthio)phenol

4-(trifluoromethylsulfinyl)phenol

2-nitro-4-(trifluoromethylsulfinyl)phenol

2-amino-4-[(trifluoromethyl)sulfinyl]phenol