(R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate

Base Information

• Chemical Name: (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate
• CAS No.: 1345876-83-6
• Molecular Formula: C₂₂H₂₂O₂
• Molecular Weight: 318.415
• Mol file: 1345876-83-6.mol

Synonyms:(R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate

Chemical Property of (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate

There total 2 articles about (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methyl-1,2-dihydronaphthalene (4373-13-1) + (E)-methyl 2-diazo-4-phenylbut-3-enoate (119987-21-2) → (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate (1345876-83-6)

Guidance literature:

With dirhodium tetrakis((R)-1-(4-bromophenyl)-2,2-diphenylcyclopropanecarboxylate); In dichloromethane; at 23 ℃; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/ja2074104

Reference yield:

4-methyl-1,2-dihydronaphthalene (4373-13-1) + (E)-methyl 2-diazo-4-phenylbut-3-enoate (119987-21-2) → (R,E)-methyl 2-((S)-4-methyl-1,2-dihydronaphthalen-2-yl)-4-phenylbut-3-enoate (1345876-83-6) + (S,3E)-methyl 2-((R)-1,2-dihydro-4-methylnaphthalen-2-yl)-4-phenylbut-3-enoate

Guidance literature:

With [Rh₂(S-DOSP)₄] embedded in the walls of cellulose acetate fiber; In hexane; at 25 ℃; Overall yield = 83 %; Overall yield = 24 mg; enantioselective reaction;

DOI:10.1002/anie.201500841

upstream raw materials:

4-methyl-1,2-dihydronaphthalene

(E)-methyl 2-diazo-4-phenylbut-3-enoate