3-acetyl-5-nitrobenzoic acid

Base Information

• Chemical Name: 3-acetyl-5-nitrobenzoic acid
• CAS No.: 717-75-9
• Molecular Formula: C9H7NO5
• Molecular Weight: 209.16
• Mol file: 717-75-9.mol

Synonyms:3-Acetyl-5-nitrobenzoicacid;

Chemical Property of 3-acetyl-5-nitrobenzoic acid

Chemical Property:

• Vapor Pressure: 3.29E-06mmHg at 25°C
• Melting Point: 174-174.5 °C
• Refractive Index: 1.6
• Boiling Point: 372.5 °C at 760 mmHg
• Flash Point: 165.2 °C
• PSA: 100.19000
• Density: 1.439 g/cm³
• LogP: 2.01880

Purity/Quality:

98%Min ^*data from raw suppliers

3-acetyl-5-nitrobenzoicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-acetyl-5-nitrobenzoic acid

There total 2 articles about 3-acetyl-5-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-methoxycarbonyl-5-nitro-benzoyl)-malonic acid diethyl ester (950225-57-7) → 5-nitro-3-acetyl benzoic acid (717-75-9)

Guidance literature:

With sulfuric acid; water; In acetic acid; Product distribution / selectivity; Heating / reflux;

Reference yield:

→ 5-nitro-3-acetyl benzoic acid (717-75-9)

Guidance literature:

3-Nitro-5-acetyl-benzonitril, 50percentig. H2SO4, 4h, 162-172grad;

Reference yield:

5-nitro-3-acetyl benzoic acid (717-75-9) + (R)-1-(4-fluorophenyl)ethylamine (374898-01-8) → 3-acetyl-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-nitro-benzamide (950225-68-0)

Guidance literature:

5-nitro-3-acetyl benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

(R)-1-(4-fluorophenyl)ethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 8h;

upstream raw materials:

2-(3-methoxycarbonyl-5-nitro-benzoyl)-malonic acid diethyl ester

Downstream raw materials:

3-acetyl-5-nitro-benzoic acid methyl ester

3-acetyl-N-[(R)-1-(4-fluoro-phenyl)-ethyl]-5-nitro-benzamide

Refernces

• 1、 -. "Process for the production of nitro derivatives of aromatic compounds". . . Retrieved 2008/06/13.