{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

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Chemical Name:{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate
CAS No.:1607592-65-3
Molecular Formula:C₂HF₃O₂*C₁₈H₁₇N₅S
Molecular Weight:449.456
Hs Code.:

Synonyms:{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

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Chemical Property of {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

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Technology Process of {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

There total 11 articles about {1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1607589-86-5
{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile

: 76-05-1
trifluoroacetic acid

: 107-91-5
cyanoacetic acid amide

: 1607592-65-3
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

Guidance literature:: cyanoacetic acid amide; With triethyloxonium fluoroborate; In tetrahydrofuran; at 20 ℃; for 2h;

{trans-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetonitrile; In ethanol; at 85 ℃; for 2h;

trifluoroacetic acid; In ethanol; water; acetonitrile;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607592-65-3
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

5.2: 2 h / 85 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607592-65-3
{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}acetonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

4.2: 2 h / 85 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; isopropyl alcohol;