2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide

Base Information

• Chemical Name: 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide
• CAS No.: 1362209-66-2
• Molecular Formula: C₂₇H₃₁Cl₃N₂O₇S
• Molecular Weight: 633.977

Synonyms:2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide

Chemical Property of 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide

There total 14 articles about 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,4S)-4-(tert-butyldimethylsilyloxy)-2-iodocyclopent-2-enol (189104-95-8) → 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide (1362209-66-2)

Guidance literature:

Multi-step reaction with 10 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 18 h / -30 °C

2: sodium hydroxide / tetrahydrofuran; methanol; water / 0.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 3.5 h / 90 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -30 - -10 °C

7: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 0.33 h / 170 °C

8: pyridine hydrogenfluoride / acetonitrile / 1 h / 20 °C

9: sulphamoyl chloride / N,N-dimethyl acetamide; acetonitrile / 0.25 h / 20 °C

10: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 1 h / 40 °C

With dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; sulphamoyl chloride; tetrabutyl ammonium fluoride; magnesium oxide; potassium carbonate; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile; 1: Mitsunobu reaction / 5: Suzuki-Miyaura coupling / 7: Overman rearrangement;

DOI:10.1021/ol300431n

Reference yield:

(R)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-ene (1287305-45-6) → 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide (1362209-66-2)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrahydrofuran / 4 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -30 - -10 °C

4: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 0.33 h / 170 °C

5: pyridine hydrogenfluoride / acetonitrile / 1 h / 20 °C

6: sulphamoyl chloride / N,N-dimethyl acetamide; acetonitrile / 0.25 h / 20 °C

7: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 1 h / 40 °C

With dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; sulphamoyl chloride; magnesium oxide; potassium carbonate; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl acetamide; acetonitrile; 2: Suzuki-Miyaura coupling / 4: Overman rearrangement;

DOI:10.1021/ol300431n

Reference yield:

(1S,4S)-4-(tert-butyldimethylsilyloxy)-2-iodocyclopent-2-en-1-yl p-nitrobenzoate → 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide (1362209-66-2)

Guidance literature:

Multi-step reaction with 9 steps

1: sodium hydroxide / tetrahydrofuran; methanol; water / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane; toluene / 3.5 h / 90 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -30 - -10 °C

6: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 0.33 h / 170 °C

7: pyridine hydrogenfluoride / acetonitrile / 1 h / 20 °C

8: sulphamoyl chloride / N,N-dimethyl acetamide; acetonitrile / 0.25 h / 20 °C

9: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 1 h / 40 °C

With dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; sulphamoyl chloride; tetrabutyl ammonium fluoride; magnesium oxide; potassium carbonate; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile; 4: Suzuki-Miyaura coupling / 6: Overman rearrangement;

DOI:10.1021/ol300431n

upstream raw materials:

(1R,4S)-4-(tert-butyldimethylsilyloxy)-2-iodocyclopent-2-enol

(R)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-ene

(1S,4S)-4-(tert-butyldimethylsilyloxy)-2-iodocyclopent-2-enol

(1S,4S)-4-((p-methoxybenzyloxy)methoxy)-3-iodocyclopent-2-enol

Downstream raw materials:

tert-butyl ((S)-2-((2R,5S,9S)-9-hydroxy-1-(2,2,2-trichloroacetyl)-1-azaspiro[4.4]non-6-en-2-yl)-1-phenylethyl)carbamate

tert-butyl ((S)-2-((2R,5S,9S)-9-(carbamoyloxy)-1-(2,2,2-trichloroacetyl)-1-azaspiro[4.4]non-6-en-2-yl)-1-phenylethyl)carbamate

tert-butyl ((S)-2-((2'S,3aS,5'R,6aS)-2-oxo-1'-(2,2,2-trichloroacetyl)-2,3,3a,6a-tetrahydrospiro[cyclopenta[d]oxazole-6,2'-pyrrolidin]-5'-yl)-1-phenylethyl)carbamate

2,6-dichloro-4-(((S)-2-((2'S,3aS,5'R,6aS)-2-oxo-1'-(2,2,2-trichloroacetyl)-2,3,3a,6a-tetrahydrospiro[cyclopenta[d]oxazole-6,2'-pyrrolidin]-5'-yl)-1-phenylethyl)carbamoyl)phenyl acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1362209-66-2 2,2,2-trichloro-N-((1S,5S)-1-(2-((4S,6S)-2,2-dioxido-4-phenyl-1,2,3-oxathiazinan-6-yl)ethyl)-5-(((p-methoxybenzyl)oxy)methoxy)cyclopent-2-en-1-yl)acetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send