4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

Base Information

Chemical Name:4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide
CAS No.:1227867-32-4
Molecular Formula:C₃₀H₃₂N₆O₃
Molecular Weight:524.622
Hs Code.:

Synonyms:4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

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Chemical Property of 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

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Technology Process of 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

There total 7 articles about 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227867-30-2
4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid

: 1227867-32-4
4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

Guidance literature:: 4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

With ammonium hydroxide; In dichloromethane; water; at 20 ℃; for 3h;

Reference yield:

: 380626-81-3
ethyl 4-amino-6-chloropyridine-3-carboxylate

: 1227867-32-4
4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C

2.1: sodium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

3.1: potassium carbonate; water / methanol / 4 h / 20 °C

4.1: phenylsilane; dibutyltin chloride / tetrahydrofuran / 72 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

6.2: 3 h / 20 °C

With pyridine; phenylsilane; dibutyltin chloride; water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1227867-19-7
6-chloro-4-(trifluoroacetyl)aminopyridine-3-carboxylic acid ethyl ester

: 1227867-32-4
4-benzylamino-6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

2.1: potassium carbonate; water / methanol / 4 h / 20 °C

3.1: phenylsilane; dibutyltin chloride / tetrahydrofuran / 72 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

5.2: 3 h / 20 °C

With phenylsilane; dibutyltin chloride; water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;