4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

Base Information

Chemical Name:4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole
CAS No.:1034688-87-3
Molecular Formula:C₂₁H₁₂F₃N₃OS
Molecular Weight:411.407
Hs Code.:

Synonyms:4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

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Technology Process of 4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

There total 1 articles about 4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952511-15-8,1035218-16-6
(Z)-N'-hydroxy-1H-indole-4-carboxamidine

: 208108-76-3
(4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid

: 1034688-87-3
4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

Guidance literature:: (4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

(Z)-N'-hydroxy-1H-indole-4-carboxamidine; In N,N-dimethyl-formamide; at 20 - 90 ℃;

Reference yield:

: 539-74-2
Ethyl 3-bromopropionate

: 1034688-87-3
4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole

: 1034687-04-1
3-(4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indol-1-yl)propanoic acid

Guidance literature:: Ethyl 3-bromopropionate; 4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole; With caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 1.5h; Microwave irradiation;

With sodium hydroxide; ethanol; water; at 20 ℃;

With hydrogenchloride; water; pH=2.5;