(-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol

Base Information

• Chemical Name: (-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol
• CAS No.: 251113-81-2
• Molecular Formula: C₂₃H₂₄N₂O₂S
• Molecular Weight: 392.522

Synonyms:(-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol

Chemical Property of (-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol

Chemical Property:

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Technology Process of (-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol

There total 1 articles about (-)-[(2S,4S,5R,S_S)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl [(SS)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate → (-)-[(2S,4S,5R,SS)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol (251113-81-2) + [(2R,4R,5S,SS)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol

Guidance literature:

With sodium tetrahydroborate; lithium iodide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1002/chem.200204674

Reference yield:

(-)-[(2S,4S,5R,SS)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol (251113-81-2) → (-)-(2S,3R,SS)-2-(benzylamino)-3-phenyl-3-(p-tolylsulfinylamino)propan-1-ol (251113-78-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;

DOI:10.1002/chem.200204674

Reference yield:

(-)-[(2S,4S,5R,SS)-2,5-diphenyl-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]methanol (251113-81-2) → (-)-(2S,3R)-3-amino-2-benzylamino-3-phenylpropan-1-ol

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 0 °C

2: 75 percent / trifluoroacetic acid / methanol / 24 h / 20 °C

With lithium aluminium tetrahydride; trifluoroacetic acid; In methanol; diethyl ether;

DOI:10.1002/chem.200204674

Downstream raw materials:

(-)-(2S,3R,S_S)-2-(benzylamino)-3-phenyl-3-(p-tolylsulfinylamino)propan-1-ol

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