Technology Process of tert-Butyl-[(1S,7R)-1-pentyl-7-(tetrahydro-pyran-2-yloxy)-octyloxy]-diphenyl-silane
There total 13 articles about tert-Butyl-[(1S,7R)-1-pentyl-7-(tetrahydro-pyran-2-yloxy)-octyloxy]-diphenyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1021/ol034338k
- Guidance literature:
-
Multi-step reaction with 12 steps
1: LiAlH4 / tetrahydrofuran / 0 °C
2: pyridine / 0 °C
3: dimethylsulfoxide / 20 °C
4: i-Bu2AlH / CH2Cl2 / -78 °C
5: 99 percent / NaH / tetrahydrofuran / 0 °C
6: i-Bu2AlH / CH2Cl2 / -78 °C
7: 89 percent / (+)-diethyl tartrate; titanium(IV) isopropoxide; t-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / -23 °C
8: 80 percent / i-Bu2AlH / CH2Cl2 / 0 °C
9: 82 percent / Bu2SnO; triethylamine / CH2Cl2 / 20 °C
10: 97 percent / K2CO3 / methanol / 20 °C
11: 97 percent / CuI / diethyl ether / -60 - -40 °C
12: 90 percent / imidazole / dimethylformamide / 20 °C
With
pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride; di(n-butyl)tin oxide; potassium carbonate; (+)-Weinsaeure-diethylester; triethylamine;
4 A molecular sieve;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
5: Wittig reaction / 7: Sharpless epoxidation;
DOI:10.1021/ol034338k
- Guidance literature:
-
Multi-step reaction with 13 steps
1: NaBH4; NiCl2*6H2O / methanol / 0 °C
2: LiAlH4 / tetrahydrofuran / 0 °C
3: pyridine / 0 °C
4: dimethylsulfoxide / 20 °C
5: i-Bu2AlH / CH2Cl2 / -78 °C
6: 99 percent / NaH / tetrahydrofuran / 0 °C
7: i-Bu2AlH / CH2Cl2 / -78 °C
8: 89 percent / (+)-diethyl tartrate; titanium(IV) isopropoxide; t-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / -23 °C
9: 80 percent / i-Bu2AlH / CH2Cl2 / 0 °C
10: 82 percent / Bu2SnO; triethylamine / CH2Cl2 / 20 °C
11: 97 percent / K2CO3 / methanol / 20 °C
12: 97 percent / CuI / diethyl ether / -60 - -40 °C
13: 90 percent / imidazole / dimethylformamide / 20 °C
With
pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride; di(n-butyl)tin oxide; potassium carbonate; (+)-Weinsaeure-diethylester; triethylamine; nickel dichloride;
4 A molecular sieve;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
6: Wittig reaction / 8: Sharpless epoxidation;
DOI:10.1021/ol034338k
