(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

Base Information

Chemical Name:(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid
CAS No.:71415-75-3
Molecular Formula:C₂₄H₃₆O₄
Molecular Weight:388.547
Hs Code.:

(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-<sup>(19)</sup>-trien-24-oic acid

Synonyms:(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

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Chemical Property of (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

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Technology Process of (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

There total 7 articles about (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 135604-81-8
methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

: 71415-75-3
(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

Guidance literature:: With potassium hydroxide; In methanol; for 20h; Ambient temperature;
DOI:10.1016/0039-128X(94)90009-4

Reference yield:

: 99221-06-4
methyl 1α,3β-dihydroxychola-5,7-dien-24-oate

: 71415-75-3
(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) irradiation, Et₂O, 2.) hexane, THF, 9 days, R_.T_.

2: 97 percent / KOH / methanol / 20 h / Ambient temperature

With potassium hydroxide; In methanol;
DOI:10.1016/0039-128X(94)90009-4

Reference yield:

: 85198-71-6
methyl 1α,3β-diacetoxychol-5-en-24-oate

: 71415-75-3
(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NBS, AIBN, 2.) 2,4,6-collidine

2: 75 percent / KOH / methanol / 2 h / Ambient temperature

3: 84 percent / 1,1,3,3-tetramethylguanidine / 0.5 h / Heating

4: 1.) irradiation, Et₂O, 2.) hexane, THF, 9 days, R_.T_.

5: 97 percent / KOH / methanol / 20 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N,N,N',N'-tetramethylguanidine; In methanol;
DOI:10.1016/0039-128X(94)90009-4