α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

Base Information

Chemical Name:α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride
CAS No.:137650-39-6
Molecular Formula:C₂₃H₃₂N₂O₃*ClH
Molecular Weight:420.98
Hs Code.:

Synonyms:α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

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Chemical Property of α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

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Technology Process of α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

There total 6 articles about α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-2-(4-Hydroxy-2,6-dimethyl-phenyl)-1-[(R)-1-methyl-2-(3-phenyl-propoxy)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

: 137650-39-6
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00080a005

Reference yield:

: 69804-99-5
3-phenylpropanol methanesulfonate

: 137650-39-6
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, a.) RT, 1 h, b.) 50 deg C, 2 h, 2.) THF, a.) 40 deg C, 16 h, b.) reflux, 2 h

2: 25 percent / H₂ / 20percent Pd/C / ethanol / 3102.9 Torr

3: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

4: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-00-1
N<1(R)-methyl-2-(3-phenylpropoxy)ethyl>-N-(phenylmethyl)benzenemethaneamine

: 137650-39-6
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-2-(3-phenylpropoxy)ethyl>benzenepropanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / H₂ / 20percent Pd/C / ethanol / 3102.9 Torr

2: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

3: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005