N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

Base Information

Chemical Name:N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester
CAS No.:131066-49-4
Molecular Formula:C₂₁H₃₃N₂O₇P
Molecular Weight:456.476
Hs Code.:

Synonyms:N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

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Chemical Property of N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

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Technology Process of N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

There total 5 articles about N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3070-69-7
methyl 2-(2-methylpropyl)acrylate

: 131066-49-4
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-43-8
N-benzyloxycarbonylaminomethyl-H-phosphinic acid

: 131066-49-4
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 2-[(Benzyloxycarbonylamino-methyl)-hydroxy-phosphinoylmethyl]-4-methyl-pentanoic acid methyl ester

: 131066-49-4
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>-L-alanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile; methanol; diethyl ether / 0 °C

2: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

3: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043