5-benzyloxy-4,6-dimethylnicotinaldehyde

Base Information

• Chemical Name: 5-benzyloxy-4,6-dimethylnicotinaldehyde
• CAS No.: 57183-26-3
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 57183-26-3.mol

Synonyms:5-benzyloxy-4,6-dimethylnicotinaldehyde

Chemical Property of 5-benzyloxy-4,6-dimethylnicotinaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-benzyloxy-4,6-dimethylnicotinaldehyde

There total 3 articles about 5-benzyloxy-4,6-dimethylnicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(5-(benzyloxy)-4,6-dimethylpyridin-3-yl)methanol (57183-08-1) → 5-benzyloxy-4,6-dimethylnicotinaldehyde (57183-26-3)

Guidance literature:

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 0.166667h;

DOI:10.1039/c4ob01221f

Reference yield:

benzyl chloride (100-44-7) → 5-benzyloxy-4,6-dimethylnicotinaldehyde (57183-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite / water; dichloromethane / 0.17 h / 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/c4ob01221f

Reference yield:

→ 5-benzyloxy-4,6-dimethylnicotinaldehyde (57183-26-3)

Guidance literature:

entspr. Alkohol 19, MnO2;

upstream raw materials:

benzyl chloride

(5-(benzyloxy)-4,6-dimethylpyridin-3-yl)methanol

Downstream raw materials:

[(5-Benzyloxy-4,6-dimethyl-pyridin-3-yl)-hydroxy-methyl]-phosphonic acid diethyl ester