(3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]

Base Information

• Chemical Name: (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]
• CAS No.: 1332488-86-4
• Molecular Formula: C₃₃H₄₆F₃NO₂Si
• Molecular Weight: 573.814

Synonyms:(3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]

Chemical Property of (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]

There total 16 articles about (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-2-iodo-4′-isopropyl-7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline] (1332488-37-5) → (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline] (1332488-86-4)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 12h; under 7500.75 Torr;

Reference yield:

1-amino-5,5-dimethylcyclohexen-3-one (873-95-0) → (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline] (1332488-86-4)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 0.17 h / 210 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 12 h / 80 °C

3.1: acetyl chloride; sodium iodide / acetonitrile / 3 h / 50 °C

4.1: (1R,2S)-1-Amino-2-indanol; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 28 h / 0 - 20 °C

5.1: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 0 - 20 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; tetrahydrofuran / 12 h / 85 °C / Inert atmosphere; Reflux

7.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

7.2: 0.08 h

8.1: Dess-Martin periodane / dichloromethane / 12 h / 0 - 20 °C

9.1: isopropylmagnesium chloride / tetrahydrofuran / 5 h / -20 °C

9.2: 12 h / -40 - 20 °C

9.3: 0.5 h / 0 °C

10.1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 36 h / 50 °C / Inert atmosphere

11.1: Iodine monochloride / dichloromethane / 24 h

12.1: triethylamine; hydrogen / palladium on activated charcoal / methanol / 12 h / 7500.75 Torr

With 2,6-dimethylpyridine; borane Ν,Ν-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; hydrogen; isopropylmagnesium chloride; Iodine monochloride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; acetyl chloride; cesium fluoride; sodium iodide; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

ethyl 2,4-diiodo-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate (1332486-29-9) → (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline] (1332488-86-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: (1R,2S)-1-Amino-2-indanol; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 28 h / 0 - 20 °C

2.1: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 0 - 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; tetrahydrofuran / 12 h / 85 °C / Inert atmosphere; Reflux

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

4.2: 0.08 h

5.1: Dess-Martin periodane / dichloromethane / 12 h / 0 - 20 °C

6.1: isopropylmagnesium chloride / tetrahydrofuran / 5 h / -20 °C

6.2: 12 h / -40 - 20 °C

6.3: 0.5 h / 0 °C

7.1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 36 h / 50 °C / Inert atmosphere

8.1: Iodine monochloride / dichloromethane / 24 h

9.1: triethylamine; hydrogen / palladium on activated charcoal / methanol / 12 h / 7500.75 Torr

With 2,6-dimethylpyridine; borane Ν,Ν-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; hydrogen; isopropylmagnesium chloride; Iodine monochloride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;

upstream raw materials:

1-chlorocyclopent-1-ene

2-cyclopent-1-enyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

1-amino-5,5-dimethylcyclohexen-3-one

ethyl 2,4-dichloro-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate

Downstream raw materials:

(3′R,9′S)-4′-isopropyl-7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinolin]-9′-ol

(3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isopropyl-7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]5′-oxide

(3′R,6′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isopropyl-7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-6′-yl acetate

(3′R,6′S,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isopropyl-7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-6′-yl acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1332488-86-4 (3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isoprorpyl-,7′,7′-dimethyl-3′-(4-(trifluoromethyl)phenyl)-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]

Send

Send

Metric Ton KG G Pound L ML

Send

Send