methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

Base Information

Chemical Name:methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate
CAS No.:1365803-20-8
Molecular Formula:C₂₅H₁₈F₃N₃O₂
Molecular Weight:449.432
Hs Code.:

Synonyms:methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

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Chemical Property of methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

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Technology Process of methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

There total 4 articles about methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1365802-74-9
methyl 4-(4-{[3-bromo-5-(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1365803-20-8
methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: methyl 4-(4-{[3-bromo-5-(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate; tri-n-butyl(vinyl)tin; With triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; sealed tube; Inert atmosphere;

With iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 1h;

Reference yield:

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1365803-20-8
methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / microwave irradiation

2.1: ethanol / 0.5 h / 100 °C / microwave irradiation

3.1: triethylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 80 °C / sealed tube; Inert atmosphere

3.2: 1 h

With potassium phosphate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 1365803-20-8
methyl 4-(4-{[3-(trifluoromethyl)-5-vinylphenyl]amino}phthalazin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 110 °C / microwave irradiation

2.1: ethanol / 0.5 h / 100 °C / microwave irradiation

3.1: triethylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 80 °C / sealed tube; Inert atmosphere

3.2: 1 h

With potassium phosphate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; toluene;