methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

Base Information

Chemical Name:methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate
CAS No.:1361414-42-7
Molecular Formula:C₂₀H₁₈N₂O₃S
Molecular Weight:366.441
Hs Code.:

Synonyms:methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

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Chemical Property of methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

Chemical Property:

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Technology Process of methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

There total 4 articles about methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361413-53-7
N-(bis(4-methoxybenzyl)carbamothioyl)benzamide

: 5467-32-3
3-(4-bromoacetyl-phenyl)-propionic acid methyl ester

: 1361414-42-7
methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

Guidance literature:: In N,N-dimethyl-formamide; at 85 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 103-25-3
3-phenylpropanoic acid methyl ester

: 1361414-42-7
methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 0 °C

1.2: 6.5 h / 0 °C

2.1: bromine / diethyl ether / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; bromine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 501-52-0
3-Phenylpropionic acid

: 1361414-42-7
methyl 3-{4-[(2-amino-4-phenyl-1,3-thiazol-5-yl)carbonyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0 °C

2.2: 6.5 h / 0 °C

3.1: bromine / diethyl ether / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; bromine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;