1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

Base Information

Chemical Name:1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine
CAS No.:251455-73-9
Molecular Formula:C₁₈H₂₅N₃O₆
Molecular Weight:379.413
Hs Code.:

Synonyms:1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

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Chemical Property of 1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

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Technology Process of 1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

There total 1 articles about 1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 30189-48-1
(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate

: 251455-73-9
1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -30 - 20 ℃;
DOI:10.1021/jm990197+

Reference yield: 31.0%

: 251455-73-9
1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

: 251455-75-1
methyl 2-{5-[(S)-1-(tert-butyloxycarbonylamino)-2-phenylethyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: 1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine; With pyridine; thionyl chloride; In tetrahydrofuran; at 0 ℃; for 2h;

In toluene; for 1.5h; Heating;
DOI:10.1021/jm990197+

Reference yield:

: 251455-73-9
1-(methoxycarbonylacetyl)-2-[(S)-2-(tert-butyloxycarbonylamino)-3-phenylpropanoyl]hydrazine

: 251455-92-2
[5-(1-tert-butoxycarbonylamino-2-phenyl-ethyl)-[1,3,4]oxadiazol-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂; pyridine / tetrahydrofuran / 2 h / 0 °C

1.2: 31 percent / toluene / 1.5 h / Heating

2.1: aq. 1 M KOH / methanol / 3 h / 20 °C

With pyridine; potassium hydroxide; thionyl chloride; In tetrahydrofuran; methanol; 1.1: Cyclization / 1.2: Dehydration / 2.1: Hydrolysis;
DOI:10.1021/jm990197+