7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

Base Information

Chemical Name:7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III
CAS No.:618887-01-7
Molecular Formula:C₄₇H₇₇IO₁₀Si₃
Molecular Weight:1013.28
Hs Code.:

Synonyms:7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

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Chemical Property of 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

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Technology Process of 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

There total 1 articles about 7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 204580-30-3
10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III

: 618-51-9
3-Iodobenzoic acid

: 618887-01-7
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

Guidance literature:: With dmap; dacarbazine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ol0354627

Reference yield:

: 618887-01-7
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

: C₂₉H₃₅IO₁₀

Guidance literature:: With pyridine hydrogenfluoride; In pyridine; acetonitrile; at 20 ℃;
DOI:10.1021/ol0354627

Reference yield:

: 618887-01-7
7,10,13-tris(triethylsilyl)-2-debenzoyl-2-(3-iodobenzoyl)-10-deacetylbaccatin III

: C₄₇H₅₃NO₁₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: HF*pyridine / pyridine; acetonitrile / 20 °C

2.1: 120 mg / imidazole / dimethylformamide / 3 h / 0 °C

3.1: 99 percent / LiHMDS / tetrahydrofuran / 2 h / -40 °C

4.1: 74 percent / LiHMDS / tetrahydrofuran / 0.67 h / -40 °C

5.1: Et₃N / Pd(PPh₃)4 / acetonitrile / 25 h / 70 °C

5.2: HF*pyridine / pyridine; acetonitrile / 22 h / 20 °C

With 1H-imidazole; pyridine hydrogenfluoride; triethylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; acetonitrile; 4.1: Ojima-Holton β-lactam ring-opening coupling / 5.1: intramolecular Heck reaction;
DOI:10.1021/ol0354627