tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Base Information

Chemical Name:tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate
CAS No.:1593269-69-2
Molecular Formula:C₃₄H₄₂N₂O₅
Molecular Weight:558.718
Hs Code.:

Synonyms:tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

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Chemical Property of tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

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Technology Process of tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

There total 7 articles about tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1311277-25-4
4-(chloromethyl)-5-ethyl-2-phenyl-1,3-oxazole

: 908598-34-5
C₂₂H₃₁NO₄

: 1593269-69-2
tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 1593269-58-9
2-benzoylamino-3-oxo-pentanoic acid ethyl ester

: 1593269-69-2
tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / chloroform / 1 h / Reflux

2: lithium borohydride / tetrahydrofuran / 1 h / Reflux

3: thionyl chloride / chloroform / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With lithium borohydride; thionyl chloride; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1593269-69-2
tert-butyl 2-[4-({[(2-phenyl-5-ethyl-1,3-oxazol-4-yl) methyl]-(furan-2-ylmethyl) amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium nitrite; acetic acid / water / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen; hydrogenchloride / ethanol / 20 °C

3: triethylammonium acetate / dichloromethane / 2 h / 20 °C

4: trichlorophosphate / chloroform / 1 h / Reflux

5: lithium borohydride / tetrahydrofuran / 1 h / Reflux

6: thionyl chloride / chloroform / 2 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylammonium acetate; potassium carbonate; acetic acid; sodium nitrite; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00513