5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Base Information

Chemical Name:5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester
CAS No.:1350629-58-1
Molecular Formula:C₃₇H₄₄N₂O₈
Molecular Weight:644.765
Hs Code.:

Synonyms:5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Suppliers and Price of 5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

There total 3 articles about 5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 143726-85-6
4-hydroxymethylbenzoic acid tert-butyl ester

: 109425-55-0,118476-89-4
Fmoc-Orn(Boc)-OH

: 1350629-58-1
5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c1ob05661a

Reference yield:

: 20576-82-3
terephthalic acid mono-tert-butyl ester

: 1350629-58-1
5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium borohydride / 18 h / 20 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With tetrabutylammonium borohydride; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05661a

Reference yield:

: 28313-42-0
di-tert-butyl terephthalate

: 1350629-58-1
5-tert-butyloxycarbonylamino-(2S)-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid (4-tert-butyloxycarbonylphenyl)methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; tert-butyl alcohol / 3 h / 50 °C / Inert atmosphere

2: tetrabutylammonium borohydride / 18 h / 20 °C / Inert atmosphere

3: dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With tetrabutylammonium borohydride; dicyclohexyl-carbodiimide; potassium hydroxide; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05661a